"Mortal Kombat vs. DC Universe" mistura universos MK e DC. Personagens mantêm Fatalities (finalizações). Funcionam em qualquer oponente; cada um tem 2.
Baraka: Stab Slam — ← → ↓ → ■ | Chest Stab — → → ↓ ↓ X
Jax: Head Smash — ← → → ← △ | Machine Gun — → → ← ← X
Kano: Knife Throw — ← ↓ ← → ■ | Flip Stomp — ↓ ↓ → ← O
Kitana: Fan Throw to Head — ← ← → ■ | Kiss of Death — → ↓ ↓ ← X
Liu Kang: MK1 Arcade Drop — → ← ↓ ↓ X | Head Stomp (1 passo longe) — ↓ ↓ → ↓ O
Raiden: Ground Slam — ↓ → ↓ ↑ △ | Electrocution — ← → → ↓ O
Sub-Zero: Freeze Kick — ← ← ↓ ← O | Freeze Slam — ← → ↓ → △
Sonya Blade: Kiss of Death — ↓ ↓ ← → ■ | Neck Breaker — ↓ ← → → O
Scorpion: Toasty — ↓ ↓ ↓ O | Lava Pool (perto) — → → ← ↓ X
Shang Tsung: Back Breaker — ← ↓ → X | Morph (perto) — ↓ ↓ → → △
Legenda: ← = Trás, → = Frente, ↓ = Baixo, ↑ = Cima, ■ = Quadrado, △ = Triângulo, X = X, O = Círculo.